Guido is a physician by training, but a scientist by heart. After a 4 years as a research fellow at the University of Michigan, he obtained a PhD at the Université Catholique de Louvain (UCL). Since 2011 he is Chercheur qualifié of the FNRS and Assistant Professor at UCL. He is trying to run his lab, which means that he tries to contribute with ideas and solutions to the progress of projects without driving people completely crazy.

The focus of his team is to combine genetic approaches and state-of-the-art analytical approaches to shed light on some dark alleys of cellular metabolism. While many projects start with a hypothesis in the field of cancer metabolism, the team follows the stream of evidence into diverse areas of human biology.

Recently, this has led to the discovery of the biogenesis of novel post-translational modifications involved in neuromuscular diseases (i.e. ribitolphosphorylation) and Parkinson's disease (i.e. N-glyceroylation and N-phosphoglyceroylation).

Publications:

Caligiore, F., Zangelmi, E., Vetro, C., Kentache, T., Dewulf, J.P., Veiga-da-Cunha, M., Van Schaftingen, E., Bommer, G., and Peracchi, A. (2022). Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates. Cell Mol Life Sci 79, 421.

Dewulf, J.P., Martin, M., Marie, S., Oguz, F., Belkhir, L., De Greef, J., Yombi, J.C., Wittebole, X., Laterre, P.F., Jadoul, M., Gatto, L., Bommer, G.T., and Morelle, J. (2022). Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19. Sci Rep 12, 9959.

Heremans, I.P., Caligiore, F., Gerin, I., Bury, M., Lutz, M., Graff, J., Stroobant, V., Vertommen, D., Teleman, A.A., Van Schaftingen, E., and Bommer, G.T. (2022). Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. Proc Natl Acad Sci U S A 119.

Johanns, M., Corbet, C., Jacobs, R., Drappier, M., Bommer, G.T., Herinckx, G., Vertommen, D., Tajeddine, N., Young, D., Messens, J., Feron, O., Steinberg, G.R., Hue, L., and Rider, M.H. (2022). Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators. Biochem J 479, 1317-1336.

Maccioni, L., Loriot, A., Dewulf, J., Bommer, G., Horsmans, Y., Lanthier, N., Leclercq, I., Schnabl, B., and Starkel, P. (2022). Duodenal CD8+ T resident memory cell apoptosis contributes to gut barrier dysfunction and microbial translocation in early alcohol-associated liver disease in humans. Aliment Pharmacol Ther 56, 1055-1070.

Clerbaux, L.A., Schultz, H., Roman-Holba, S., Ruan, D.F., Yu, R., Lamb, A.M., Bommer, G.T., and Kennell, J.A. (2021). The microRNA miR-33 is a pleiotropic regulator of metabolic and developmental processes in Drosophila melanogaster. Dev Dyn 250, 1634-1650.

Dewulf, J.P., Paquay, S., Marbaix, E., Achouri, Y., Van Schaftingen, E., and Bommer, G.T. (2021). ECHDC1 knockout mice accumulate ethyl-branched lipids and excrete abnormal intermediates of branched-chain fatty acid metabolism. J Biol Chem 297, 101083.

Kentache, T., Thabault, L., Deumer, G., Haufroid, V., Frederick, R., Linster, C.L., Peracchi, A., Veiga-da-Cunha, M., Bommer, G.T., and Van Schaftingen, E. (2021). The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate. J Biol Chem 296, 100699.

Morava, E., Schatz, U.A., Torring, P.M., Abbott, M.A., Baumann, M., Brasch-Andersen, C., Chevalier, N., Dunkhase-Heinl, U., Fleger, M., Haack, T.B., Nelson, S., Potelle, S., Radenkovic, S., Bommer, G.T., Van Schaftingen, E., and Veiga-da-Cunha, M. (2021). Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder. Am J Hum Genet 108, 1151-1160.

Ury, B., Potelle, S., Caligiore, F., Whorton, M.R., and Bommer, G.T. (2021). The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. J Biol Chem 296, 100789.

Bommer, G.T., Van Schaftingen, E., and Veiga-da-Cunha, M. (2020). Metabolite Repair Enzymes Control Metabolic Damage in Glycolysis. Trends Biochem Sci 45, 228-243.

Darius, T., Vergauwen, M., Smith, T., Gerin, I., Joris, V., Mueller, M., Aydin, S., Muller, X., Schlegel, A., Nath, J., Ludwig, C., Dessy, C., Many, M.C., Bommer, G., Dutkowski, P., Gianello, P., and Mourad, M. (2020). Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model. Am J Transplant 20, 2030-2043.

Kentache, T., Thabault, L., Peracchi, A., Frederick, R., Bommer, G.T., and Van Schaftingen, E. (2020). The putative Escherichia coli dehydrogenase YjhC metabolises two dehydrated forms of N-acetylneuraminate produced by some sialidases. Biosci Rep 40.

Veiga-da-Cunha, M., Van Schaftingen, E., and Bommer, G.T. (2020). Inborn errors of metabolite repair. J Inherit Metab Dis 43, 14-24.

Dewulf, J.P., Gerin, I., Rider, M.H., Veiga-da-Cunha, M., Van Schaftingen, E., and Bommer, G.T. (2019). The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA. Biochem J 476, 2427-2447.

Gerin, I., Bury, M., Baldin, F., Graff, J., Van Schaftingen, E., and Bommer, G.T. (2019). Phosphoglycolate has profound metabolic effects but most likely no role in a metabolic DNA response in cancer cell lines. Biochem J 476, 629-643.

Marbaix, A.Y., Chehade, G., Noel, G., Morsomme, P., Vertommen, D., Bommer, G.T., and Van Schaftingen, E. (2019). Pyridoxamine-phosphate oxidases and pyridoxamine-phosphate oxidase-related proteins catalyze the oxidation of 6-NAD(P)H to NAD(P). Biochem J 476, 3033-3052.

Veiga-da-Cunha, M., Chevalier, N., Stephenne, X., Defour, J.P., Paczia, N., Ferster, A., Achouri, Y., Dewulf, J.P., Linster, C.L., Bommer, G.T., and Van Schaftingen, E. (2019). Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proc Natl Acad Sci U S A 116, 1241-1250.

Wiame, E., Tahay, G., Tyteca, D., Vertommen, D., Stroobant, V., Bommer, G.T., and Van Schaftingen, E. (2018). NAT6 acetylates the N-terminus of different forms of actin. FEBS J 285, 3299-3316.

Peracchi, A., Veiga-da-Cunha, M., Kuhara, T., Ellens, K.W., Paczia, N., Stroobant, V., Seliga, A.K., Marlaire, S., Jaisson, S., Bommer, G.T., Sun, J., Huebner, K., Linster, C.L., Cooper, A.J.L., and Van Schaftingen, E. (2017). Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A 114, E3233-E3242.

Bommer, G.T., Baldin, F., and Van Schaftingen, E. (2016). Accumulation of metabolic side products might favor the production of ethanol in Pho13 knockout strains. Microb Cell 3, 495-499.

Collard, F., Baldin, F., Gerin, I., Bolsee, J., Noel, G., Graff, J., Veiga-da-Cunha, M., Stroobant, V., Vertommen, D., Houddane, A., Rider, M.H., Linster, C.L., Van Schaftingen, E., and Bommer, G.T. (2016). A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Nat Chem Biol 12, 601-607.

Gerin, I., Ury, B., Breloy, I., Bouchet-Seraphin, C., Bolsee, J., Halbout, M., Graff, J., Vertommen, D., Muccioli, G.G., Seta, N., Cuisset, J.M., Dabaj, I., Quijano-Roy, S., Grahn, A., Van Schaftingen, E., and Bommer, G.T. (2016). ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto alpha-dystroglycan. Nat Commun 7, 11534.

Villacorte, M., Delmarcelle, A.S., Lernoux, M., Bouquet, M., Lemoine, P., Bolsee, J., Umans, L., de Sousa Lopes, S.C., Van Der Smissen, P., Sasaki, T., Bommer, G., Henriet, P., Refetoff, S., Lemaigre, F.P., Zwijsen, A., Courtoy, P.J., and Pierreux, C.E. (2016). Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development 143, 1958-1970.

Arts, N., Cane, S., Hennequart, M., Lamy, J., Bommer, G., Van den Eynde, B., and De Plaen, E. (2015). microRNA-155, induced by interleukin-1ss, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. PLoS One 10, e0122517.

Gerin, I., Noel, G., Bolsee, J., Haumont, O., Van Schaftingen, E., and Bommer, G.T. (2014). Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase. Biochem J 458, 439-448.

Feng, Y., Sentani, K., Wiese, A., Sands, E., Green, M., Bommer, G.T., Cho, K.R., and Fearon, E.R. (2013). Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation. Am J Pathol 183, 493-503.

Gauthy, E., Cuende, J., Stockis, J., Huygens, C., Lethe, B., Collet, J.F., Bommer, G., Coulie, P.G., and Lucas, S. (2013). GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PLoS One 8, e76186.

Pachikian, B.D., Essaghir, A., Demoulin, J.B., Catry, E., Neyrinck, A.M., Dewulf, E.M., Sohet, F.M., Portois, L., Clerbaux, L.A., Carpentier, Y.A., Possemiers, S., Bommer, G.T., Cani, P.D., and Delzenne, N.M. (2013). Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways. Mol Nutr Food Res 57, 347-359.

Bommer, G.T., and MacDougald, O.A. (2011). Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus. Cell Metab 13, 241-247.

Fearon, E.R., and Bommer, G.T. (2011). Ancestries hidden in plain sight: methylation patterns for clonal analysis. Gastroenterology 140, 1139-1143.

Feng, Y., Bommer, G.T., Zhao, J., Green, M., Sands, E., Zhai, Y., Brown, K., Burberry, A., Cho, K.R., and Fearon, E.R. (2011). Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool. Gastroenterology 141, 1003-1013 e1001-1010.

Linster, C.L., Noel, G., Stroobant, V., Vertommen, D., Vincent, M.F., Bommer, G.T., Veiga-da-Cunha, M., and Van Schaftingen, E. (2011). Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. J Biol Chem 286, 42992-43003.

Bommer, G.T., Feng, Y., Iura, A., Giordano, T.J., Kuick, R., Kadikoy, H., Sikorski, D., Wu, R., Cho, K.R., and Fearon, E.R. (2010). IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem 285, 1928-1938.

Gerin, I., Bommer, G.T., McCoin, C.S., Sousa, K.M., Krishnan, V., and MacDougald, O.A. (2010a). Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab 299, E198-206.

Gerin, I., Clerbaux, L.A., Haumont, O., Lanthier, N., Das, A.K., Burant, C.F., Leclercq, I.A., MacDougald, O.A., and Bommer, G.T. (2010b). Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem 285, 33652-33661.

Reka, A.K., Kurapati, H., Narala, V.R., Bommer, G., Chen, J., Standiford, T.J., and Keshamouni, V.G. (2010). Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition. Mol Cancer Ther 9, 3221-3232.

Watson, R.L., Spalding, A.C., Zielske, S.P., Morgan, M., Kim, A.C., Bommer, G.T., Eldar-Finkelman, H., Giordano, T., Fearon, E.R., Hammer, G.D., Lawrence, T.S., and Ben-Josef, E. (2010). GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer. Neoplasia 12, 357-365.

Zhai, Y., Bommer, G.T., Feng, Y., Wiese, A.B., Fearon, E.R., and Cho, K.R. (2010). Loss of estrogen receptor 1 enhances cervical cancer invasion. Am J Pathol 177, 884-895.

Gerin, I., Bommer, G.T., Lidell, M.E., Cederberg, A., Enerback, S., and Macdougald, O.A. (2009). On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake. J Biol Chem 284, 10755-10763.

Herbst, A., Bommer, G.T., Kriegl, L., Jung, A., Behrens, A., Csanadi, E., Gerhard, M., Bolz, C., Riesenberg, R., Zimmermann, W., Dietmaier, W., Wolf, I., Brabletz, T., Goke, B., and Kolligs, F.T. (2009). ITF-2 is disrupted via allelic loss of chromosome 18q21, and ITF-2B expression is lost at the adenoma-carcinoma transition. Gastroenterology 137, 639-648, 648 e631-639.

Ji, Q., Hao, X., Zhang, M., Tang, W., Yang, M., Li, L., Xiang, D., Desano, J.T., Bommer, G.T., Fan, D., Fearon, E.R., Lawrence, T.S., and Xu, L. (2009). MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 4, e6816.

Rowe, R.G., Li, X.Y., Hu, Y., Saunders, T.L., Virtanen, I., Garcia de Herreros, A., Becker, K.F., Ingvarsen, S., Engelholm, L.H., Bommer, G.T., Fearon, E.R., and Weiss, S.J. (2009). Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol 184, 399-408.

Akyol, A., Hinoi, T., Feng, Y., Bommer, G.T., Glaser, T.M., and Fearon, E.R. (2008). Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods 5, 231-233.

Bommer, J., Asmus, G., Wenning, M., and Bommer, G. (2008). A comparison of haemoglobin levels and doses in haemodialysis patients treated with subcutaneous or intravenous darbepoetin alfa: a German prospective, randomized, multicentre study. Nephrol Dial Transplant 23, 4002-4008.

Bommer, G.T., and Fearon, E.R. (2007). Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning? Cancer Cell 11, 391-394.

Bommer, G.T., Gerin, I., Feng, Y., Kaczorowski, A.J., Kuick, R., Love, R.E., Zhai, Y., Giordano, T.J., Qin, Z.S., Moore, B.B., MacDougald, O.A., Cho, K.R., and Fearon, E.R. (2007). p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17, 1298-1307.

Feng, Y., Bommer, G.T., Zhai, Y., Akyol, A., Hinoi, T., Winer, I., Lin, H.V., Cadigan, K.M., Cho, K.R., and Fearon, E.R. (2007). Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. Cancer Res 67, 482-491.

Winer, I.S., Bommer, G.T., Gonik, N., and Fearon, E.R. (2006). Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation. J Biol Chem 281, 26181-26187.

Bommer, G.T., Jager, C., Durr, E.M., Baehs, S., Eichhorst, S.T., Brabletz, T., Hu, G., Frohlich, T., Arnold, G., Kress, D.C., Goke, B., Fearon, E.R., and Kolligs, F.T. (2005). DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells. J Biol Chem 280, 7962-7975.

Lenhard, K., Bommer, G.T., Asutay, S., Schauer, R., Brabletz, T., Goke, B., Lamerz, R., and Kolligs, F.T. (2005). Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol 3, 142-149.

Horndasch, M., Raschke, E.E., Bommer, G., Schuhmacher, M., Dumont, E., Kuklik-Roos, C., Eick, D., and Kempkes, B. (2002). Epstein-Barr virus antagonizes the antiproliferative activity of transforming growth factor-beta but does not abolish its signaling. Int J Cancer 101, 442-447.

Kolligs, F.T., Bommer, G., and Goke, B. (2002). Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis. Digestion 66, 131-144.

Fuchs, K.P., Bommer, G., Dumont, E., Christoph, B., Vidal, M., Kremmer, E., and Kempkes, B. (2001). Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction. Eur J Biochem 268, 4639-4646.

Dumont, E., Fuchs, K.P., Bommer, G., Christoph, B., Kremmer, E., and Kempkes, B. (2000). Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling. Oncogene 19, 556-561.